Endocrine Abstracts

The Polymerase Chain Reaction is going through a renaissance with the arrival of new Digital PCR instrumentation. Amongst these, Droplet Digital PCR is embraced by the research community as an affordable, high resolution quantitative and detection analysis solution for nucleic acids. This presentation will cover the concept of digital PCR, absolute and standard free quantitation of nucleic acid targets as well as applications; CNV analysis, Mutation Abundance, Single cell expr...

Hormone release by pituitary cell types is primarily regulated by stimulatory and inhibitory factors secreted by the hypothalamus. In turn, factors produced by the target organs controlled by the pituitary exert a feedback regulation on the corresponding pituitary cells. However, recent data indicate that, besides these factors, other mechanisms operate to finely tune pituitary function. These include both novel peripheral regulatory factors as well as intrinsic cellular eleme...

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

Introduction: Gestational diabetes mellitus (GDM) is a carbohydrate intolerance with onset or recognition during pregnancy. Timely screening and proper management of this condition is essencial to maximize pregnancy and neonatal outcomes.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns, followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated.Results: From...

Introduction: Gestational Diabetes Mellitus (GDM) is a pregnancy complication that has experienced a worldwide growth. The use of insulin has to be considered as it may be beneficial for both the mother and the new-born.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns (NB), followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated in 2 groups: GDM with no insulin therapy (GDMNIT)...

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...

Background: Lithium salts have been widely known to induce thyroid dysfunction, however, parathyroid dysfunction due to lithium use is uncommonly encountered. Hypercalcemia is a relatively common consequence of lithium therapy presenting with nonspecific symptoms that may be overlooked. Although cerebral infarction may be an independent event from psychiatric disorders, it can also be a rare complication that must be recognized particularly in patients on lithium therapy.<...

The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of oxidative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is also yet to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of oxidative stress and antioxidants in women with GDM, which potentially may have considerable clinic...

69-year-old male, with a history of bipolar disorder under treatment, smoker and high blood pressure. He is referred for left adrenal injury detected incidentally by secondary hypertension study. Abdominal CT shows a mass of 67.7×51.8×52.3 mm in the left adrenal area, with radiological characteristics of malignancy and aggressive behavior, contacting the left renal pole and upper splenic pole, compatible with adrenal carcinoma vs. metastasis. The functional study is ...

Background: Pheochromocytomas (PHEO) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla. Catecholamins’ secretion is associated with a high risk of cardiovascular complications. Malignancy is rare, but still demands effective treatment. Metformin has been shown to have antiproliferative properties in several cancer cell lines, possibly related to its ability to inhibit cell proliferation pathways. Accordingly, we aimed to evaluate the effe...